Title | Imaging-based clusters in former smokers of the COPD cohort associate with clinical characteristics: the SubPopulations and intermediate outcome measures in COPD study (SPIROMICS). |
Publication Type | Publication |
Year | 2019 |
Authors | Haghighi B, Choi S, Choi J, Hoffman EA, Comellas AP, Newell JD, Lee CHyun, R Barr G, Bleecker E, Cooper CB, Couper D, Han MLan, Hansel NN, Kanner RE, Kazerooni EA, Kleerup EAC, Martinez FJ, O'Neal W, Paine R, Rennard SI, Smith BM, Woodruff PG, Lin C-L |
Journal | Respir Res |
Volume | 20 |
Issue | 1 |
Pagination | 153 |
Date Published | 2019 Jul 15 |
ISSN | 1465-993X |
Keywords | Aged, Cohort Studies, Cross-Sectional Studies, Female, Forced Expiratory Volume, Humans, Imaging, Three-Dimensional, Male, Middle Aged, Outcome Assessment, Health Care, Pulmonary Disease, Chronic Obstructive, smoking, Tomography, X-Ray Computed |
Abstract | BACKGROUND: Quantitative computed tomographic (QCT) imaging-based metrics enable to quantify smoking induced disease alterations and to identify imaging-based clusters for current smokers. We aimed to derive clinically meaningful sub-groups of former smokers using dimensional reduction and clustering methods to develop a new way of COPD phenotyping.METHODS: An imaging-based cluster analysis was performed for 406 former smokers with a comprehensive set of imaging metrics including 75 imaging-based metrics. They consisted of structural and functional variables at 10 segmental and 5 lobar locations. The structural variables included lung shape, branching angle, airway-circularity, airway-wall-thickness, airway diameter; the functional variables included regional ventilation, emphysema percentage, functional small airway disease percentage, Jacobian (volume change), anisotropic deformation index (directional preference in volume change), and tissue fractions at inspiration and expiration.RESULTS: We derived four distinct imaging-based clusters as possible phenotypes with the sizes of 100, 80, 141, and 85, respectively. Cluster 1 subjects were asymptomatic and showed relatively normal airway structure and lung function except airway wall thickening and moderate emphysema. Cluster 2 subjects populated with obese females showed an increase of tissue fraction at inspiration, minimal emphysema, and the lowest progression rate of emphysema. Cluster 3 subjects populated with older males showed small airway narrowing and a decreased tissue fraction at expiration, both indicating air-trapping. Cluster 4 subjects populated with lean males were likely to be severe COPD subjects showing the highest progression rate of emphysema.CONCLUSIONS: QCT imaging-based metrics for former smokers allow for the derivation of statistically stable clusters associated with unique clinical characteristics. This approach helps better categorization of COPD sub-populations; suggesting possible quantitative structural and functional phenotypes. |
DOI | 10.1186/s12931-019-1121-z |
Alternate Journal | Respir Res |
PubMed ID | 31307479 |
PubMed Central ID | PMC6631615 |
Grant List | U24 HL141762 / HL / NHLBI NIH HHS / United States S10 OD018526 / OD / NIH HHS / United States P30 CA086862 / CA / NCI NIH HHS / United States K24 HL137013 / HL / NHLBI NIH HHS / United States U01 HL114494 / HL / NHLBI NIH HHS / United States U01 HL137880 / HL / NHLBI NIH HHS / United States R01 HL130506 / HL / NHLBI NIH HHS / United States S10 RR022421 / RR / NCRR NIH HHS / United States R01 HL112986 / HL / NHLBI NIH HHS / United States P30 ES005605 / ES / NIEHS NIH HHS / United States NIH grants U01-HL114494, R01-HL112986 and S10-RR022421 / NH / NIH HHS / United States P30 ES006694 / ES / NIEHS NIH HHS / United States |
Imaging-based clusters in former smokers of the COPD cohort associate with clinical characteristics: the SubPopulations and intermediate outcome measures in COPD study (SPIROMICS).
MS#:
MS200
Manuscript Full Title:
Imaging-based clusters in former smokers of the COPD cohort associate with clinical characteristics: the SubPopulations and intermediate outcome measures in COPD study (SPIROMICS).
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Published and Public