Age-Dependent Associations Between 25-Hydroxy Vitamin D Levels and COPD Symptoms: Analysis of SPIROMICS.

TitleAge-Dependent Associations Between 25-Hydroxy Vitamin D Levels and COPD Symptoms: Analysis of SPIROMICS.
Publication TypePublication
Year2021
AuthorsBurkes RM, Couper DJ, Barjaktarevic IZ, Cooper CB, Labaki WW, Han MK, Woodruff PG, Lazarus SC, Parekh TM, Paine R, Comellas AP, Bowler RP, Loehr LR, Putcha N, Wise RA, Brown TT, M Drummond B
JournalChronic Obstr Pulm Dis
Volume8
Issue2
Pagination277-291
Date Published2021 Apr 27
ISSN2372-952X
Abstract

INTRODUCTION: Age and vitamin D levels may affect symptom burden in chronic obstructive pulmonary disease (COPD). We used the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS) to determine independent associations between vitamin D levels and COPD symptoms in different age strata.METHODS: Serum 25-hydroxy (OH)-vitamin D levels were modeled continuously and categorically (<20 ng/ml versus ≥20 ng/ml). Stratifying by age group (middle-age: 40-64 years old and older: >65 years old), multivariable modeling was performed to identify relationships between 25-OH-vitamin D levels and the COPD Assessment Test (CAT), the modified Medical Research Council score (mMRC), the St George's Respiratory Questionnaire (SGRQ) total and subdomain scores, the Veterans' Specific Activity Questionnaire, and the 6-minute walk test distance.RESULTS: InIn the middle-aged group, each 5 ng/ml higher 25-OH-vitamin D level was independently associated with more favorable CAT score (-0.35 [-0.67 to -0.03], =0.03), total SGRQ (-0.91 [-1.65 to -0.17]; =0.02), and the SGRQ subdomains (Symptoms:-1.07 [-1.96 to -0.18], =0.02; Impact: -0.77 [-1.53 to -0.003], =0.049; Activity: -1.07 [-1.96 to -0.18], =0.02). These associations persisted after the addition of comorbidity score, reported vitamin D supplementation, outdoor time, or season of blood draw to models. No associations were observed between 25-OH-vitamin D levels and symptom scores in the older age group.DISCUSSION: When controlled for clinically relevant covariates, higher 25-OH-vitamin D levels are associated with more favorable respiratory-specific symptoms and quality-of-life assessments in middle-age but not older COPD individuals. Study of the role of vitamin D supplementation in the symptom burden of younger COPD patients is needed.

DOI10.15326/jcopdf.2020.0180
Alternate JournalChronic Obstr Pulm Dis
PubMed ID33829714
PubMed Central IDPMC8237982
Grant ListHHSN268200900013C/ / HB / NHLBI NIH HHS / United States
/ / Foundation for the NIH / United States
/ / COPD Foundation / United States
R01 HL125432 / HL / NHLBI NIH HHS / United States
R01HL125432 / HB / NHLBI NIH HHS / United States
U24 HL141762 / HL / NHLBI NIH HHS / United States
F32HL143867 / HB / NHLBI NIH HHS / United States
MS#: 
MS158
Manuscript Full Title: 
Age-Dependent Associations Between 25-Hydroxy Vitamin D Levels and COPD Symptoms: Analysis of SPIROMICS.
Manuscript Lead/Corresponding Author Affiliation: 
Genomics and Informatics Center (University of North Carolina at Chapel Hill)
ECI: 
Manuscript Status: 
Published and Public