Lung microbiota associations with clinical features of COPD in the SPIROMICS cohort.

TitleLung microbiota associations with clinical features of COPD in the SPIROMICS cohort.
Publication TypePublication
Year2021
AuthorsOpron K, Begley LA, Erb-Downward JR, Freeman C, Madapoosi S, Alexis NE, Barjaktarevic I, R Barr G, Bleecker ER, Bowler RP, Christenson SA, Comellas AP, Cooper CB, Couper DJ, Doerschuk CM, Dransfield MT, Han MK, Hansel NN, Hastie AT, Hoffman EA, Kaner RJ, Krishnan J, O'Neal WK, Ortega VE, Paine R, Peters SP, J Wells M, Woodruff PG, Martinez FJ, Curtis JL, Huffnagle GB, Huang YJ
JournalNPJ Biofilms Microbiomes
Volume7
Issue1
Pagination14
Date Published2021 02 05
ISSN2055-5008
KeywordsAdult, Aged, Bacteria, Bronchoalveolar Lavage Fluid, Female, Forced Expiratory Volume, Humans, Lung, Male, Middle Aged, Pulmonary Disease, Chronic Obstructive, RNA, Ribosomal, 16S, Sequence Analysis, RNA, Spirometry
Abstract

Chronic obstructive pulmonary disease (COPD) is heterogeneous in development, progression, and phenotypes. Little is known about the lung microbiome, sampled by bronchoscopy, in milder COPD and its relationships to clinical features that reflect disease heterogeneity (lung function, symptom burden, and functional impairment). Using bronchoalveolar lavage fluid collected from 181 never-smokers and ever-smokers with or without COPD (GOLD 0-2) enrolled in the SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS), we find that lung bacterial composition associates with several clinical features, in particular bronchodilator responsiveness, peak expiratory flow rate, and forced expiratory flow rate between 25 and 75% of FVC (FEF). Measures of symptom burden (COPD Assessment Test) and functional impairment (six-minute walk distance) also associate with disparate lung microbiota composition. Drivers of these relationships include members of the Streptococcus, Prevotella, Veillonella, Staphylococcus, and Pseudomonas genera. Thus, lung microbiota differences may contribute to airway dysfunction and airway disease in milder COPD.

DOI10.1038/s41522-021-00185-9
Alternate JournalNPJ Biofilms Microbiomes
PubMed ID33547327
PubMed Central IDPMC7865064
Grant ListHHSN268200900019C / HL / NHLBI NIH HHS / United States
U24 HL141762 / HL / NHLBI NIH HHS / United States
R01 HL121774 / HL / NHLBI NIH HHS / United States
HHSN268200900015C / HL / NHLBI NIH HHS / United States
HHSN268200900016C / HL / NHLBI NIH HHS / United States
U01 HL137880 / HL / NHLBI NIH HHS / United States
HHSN268200900013C / HL / NHLBI NIH HHS / United States
R01 AI129958 / AI / NIAID NIH HHS / United States
HHSN268200900014C / HL / NHLBI NIH HHS / United States
R03 HL138310 / HL / NHLBI NIH HHS / United States
K23 HL123778 / HL / NHLBI NIH HHS / United States
K24 HL137013 / HL / NHLBI NIH HHS / United States
HHSN268200900018C / HL / NHLBI NIH HHS / United States
P30 DK054759 / DK / NIDDK NIH HHS / United States
HHSN268200900017C / HL / NHLBI NIH HHS / United States
HHSN268200900020C / HL / NHLBI NIH HHS / United States
MS#: 
MS209
Manuscript Full Title: 
Lung microbiota associations with clinical features of COPD in the SPIROMICS cohort.
Manuscript Lead/Corresponding Author Affiliation: 
Clinical Center: Michigan (University of Michigan)
ECI: 
Manuscript Status: 
Published and Public