NumberTitleAuthorsSiteYearJournalPubMed IDPMCID
MS183Forced Expiratory Flow at 25%-75% Links COPD Physiology to Emphysema and Disease Severity in the SPIROMICS Cohort.Ronish, Bonnie E.; Couper, David J.; Barjaktarevic, Igor Z.; Cooper, Christopher B.; Kanner, Richard E.; Pirozzi, Cheryl S.; Kim, Victor ; Wells, James M.; Han, Meilan K.; Woodruff, Prescott G.; Ortega, Victor E.; Peters, Stephen P.; Hoffman, Eric A.; Buhr, Russell G.; Dolezal, Brett A.; Tashkin, Donald P.; Liou, Theodore G.; Bateman, Lori A.; Schroeder, Joyce D.; Martinez, Fernando J.; Barr, Graham ; Hansel, Nadia N.; Comellas, Alejandro P.; Rennard, Stephen I.; Arjomandi, Mehrdad ; Iii, Robert PaineClinical Center: Utah (University of Utah)2022Chronic Obstr Pulm Dishttps://pubmed.ncbi.nlm.nih.gov/35114743
MS158Age-Dependent Associations Between 25-Hydroxy Vitamin D Levels and COPD Symptoms: Analysis of SPIROMICS.Burkes, Robert M.; Couper, David J.; Barjaktarevic, Igor Z.; Cooper, Christopher B.; Labaki, Wassim W.; Han, Meilan K.; Woodruff, Prescott G.; Lazarus, Stephen C.; Parekh, Trisha M.; Paine, Robert ; Comellas, Alejandro P.; Bowler, Russell P.; Loehr, Laura R.; Putcha, Nirupama ; Wise, Robert A.; Brown, Todd T.; Drummond, Bradley Genomics and Informatics Center (University of North Carolina at Chapel Hill)2021Chronic Obstr Pulm Dishttps://pubmed.ncbi.nlm.nih.gov/33829714https://www.ncbi.nlm.nih.gov/pmc/PMC8237982
MS219Airway mucin MUC5AC and MUC5B concentrations and the initiation and progression of chronic obstructive pulmonary disease: an analysis of the SPIROMICS cohort.Radicioni, Giorgia ; Ceppe, Agathe ; Ford, Amina A.; Alexis, Neil E.; Barr, Graham ; Bleecker, Eugene R.; Christenson, Stephanie A.; Cooper, Christopher B.; Han, Meilan K.; Hansel, Nadia N.; Hastie, Annette T.; Hoffman, Eric A.; Kanner, Richard E.; Martinez, Fernando J.; Ozkan, Esin ; Paine, Robert ; Woodruff, Prescott G.; O'Neal, Wanda K.; Boucher, Richard C.; Kesimer, Mehmet Genomics and Informatics Center (University of North Carolina at Chapel Hill)2021Lancet Respir Medhttps://pubmed.ncbi.nlm.nih.gov/34058148https://www.ncbi.nlm.nih.gov/pmc/PMC8570975
MS194Association of plasma mitochondrial DNA with COPD severity and progression in the SPIROMICS cohort.Zhang, William Z.; Hoffman, Katherine L.; Schiffer, Kristen T.; Oromendia, Clara ; Rice, Michelle C.; Barjaktarevic, Igor ; Peters, Stephen P.; Putcha, Nirupama ; Bowler, Russell P.; Wells, Michael ; Couper, David J.; Labaki, Wassim W.; Curtis, Jeffrey L.; Han, Meilan K.; Paine, Robert ; Woodruff, Prescott G.; Criner, Gerard J.; Hansel, Nadia N.; Diaz, Ivan ; Ballman, Karla V.; Nakahira, Kiichi ; Choi, Mary E.; Martinez, Fernando J.; Choi, Augustine M.K.; Cloonan, Suzanne M.Weill Cornell Medical Center2021Respir Reshttps://pubmed.ncbi.nlm.nih.gov/33902556https://www.ncbi.nlm.nih.gov/pmc/PMC8074408
MS178Contribution of Individual and Neighborhood Factors to Racial Disparities in Respiratory Outcomes.Ejike, Chinedu O.; Woo, Han ; Galiatsatos, Panagis ; Paulin, Laura M.; Krishnan, Jerry A.; Cooper, Christopher B.; Couper, David J.; Kanner, Richard E.; Bowler, Russell P.; Hoffman, Eric A.; Comellas, Alejandro P.; Criner, Gerard J.; Barr, Graham ; Martinez, Fernando J.; Han, Meilan K.; Martinez, Carlos H.; Ortega, Victor E.; Parekh, Trisha M.; Christenson, Stephanie A.; Thakur, Neeta ; Baugh, Aaron ; Belz, Daniel C.; Raju, Sarath ; Gassett, Amanda J.; Kaufman, Joel D.; Putcha, Nirupama ; Hansel, Nadia N.Clinical Center: Baltimore (Johns Hopkins University)2021Am J Respir Crit Care Medhttps://pubmed.ncbi.nlm.nih.gov/33007162https://www.ncbi.nlm.nih.gov/pmc/PMC8048743
MS190Defining Resilience to Smoking-related Lung Disease: A Modified Delphi Approach from SPIROMICS.Oh, Anita L.; Mularski, Richard A.; Barjaktarevic, Igor ; Barr, Graham ; Bowler, Russell P.; Comellas, Alejandro P.; Cooper, Christopher B.; Criner, Gerard J.; Han, Meilan K.; Hansel, Nadia N.; Hoffman, Eric A.; Kanner, Richard E.; Krishnan, Jerry A.; Paine, Robert ; Parekh, Trisha M.; Peters, Stephen P.; Christenson, Stephanie A.; Woodruff, Prescott G.Clinical Center: San Francisco (University of California at San Francisco)2021Ann Am Thorac Sochttps://pubmed.ncbi.nlm.nih.gov/33631079https://www.ncbi.nlm.nih.gov/pmc/PMC8641833
MS242Genetic and non-genetic factors affecting the expression of COVID-19-relevant genes in the large airway epithelium.Kasela, Silva ; Ortega, Victor E.; Martorella, Molly ; Garudadri, Suresh ; Nguyen, Jenna ; Ampleford, Elizabeth ; Pasanen, Anu ; Nerella, Srilaxmi ; Buschur, Kristina L.; Barjaktarevic, Igor Z.; Barr, Graham ; Bleecker, Eugene R.; Bowler, Russell P.; Comellas, Alejandro P.; Cooper, Christopher B.; Couper, David J.; Criner, Gerard J.; Curtis, Jeffrey L.; Han, Meilan K.; Hansel, Nadia N.; Hoffman, Eric A.; Kaner, Robert J.; Krishnan, Jerry A.; Martinez, Fernando J.; McDonald, Merry-Lynn N.; Meyers, Deborah A.; Paine, Robert ; Peters, Stephen P.; Castro, Mario ; Denlinger, Loren C.; Erzurum, Serpil C.; Fahy, John V.; Israel, Elliot ; Jarjour, Nizar N.; Levy, Bruce D.; Li, Xingnan ; Moore, Wendy C.; Wenzel, Sally E.; Zein, Joe ; Langelier, Charles ; Woodruff, Prescott G.; Lappalainen, Tuuli ; Christenson, Stephanie A.Clinical Center: San Francisco (University of California at San Francisco)2021Genome Medhttps://pubmed.ncbi.nlm.nih.gov/33883027https://www.ncbi.nlm.nih.gov/pmc/PMC8059115
MS200Latent traits of lung tissue patterns in former smokers derived by dual channel deep learning in computed tomography images.Li, Frank ; Choi, Jiwoong ; Zou, Chunrui ; Newell, John D.; Comellas, Alejandro P.; Lee, Chang Hyun; Ko, Hongseok ; Barr, Graham ; Bleecker, Eugene R.; Cooper, Christopher B.; Abtin, Fereidoun ; Barjaktarevic, Igor ; Couper, David ; Han, MeiLan ; Hansel, Nadia N.; Kanner, Richard E.; Paine, Robert ; Kazerooni, Ella A.; Martinez, Fernando J.; O'Neal, Wanda ; Rennard, Stephen I.; Smith, Benjamin M.; Woodruff, Prescott G.; Hoffman, Eric A.; Lin, Ching-Long Clinical Center: Iowa (University of Iowa)2021Sci Rephttps://pubmed.ncbi.nlm.nih.gov/33649381https://www.ncbi.nlm.nih.gov/pmc/PMC7921389
MS209Lung microbiota associations with clinical features of COPD in the SPIROMICS cohort.Opron, Kristopher ; Begley, Lesa A.; Erb-Downward, John R.; Freeman, Christine ; Madapoosi, Siddharth ; Alexis, Neil E.; Barjaktarevic, Igor ; Barr, Graham ; Bleecker, Eugene R.; Bowler, Russell P.; Christenson, Stephanie A.; Comellas, Alejandro P.; Cooper, Christopher B.; Couper, David J.; Doerschuk, Claire M.; Dransfield, Mark T.; Han, Meilan K.; Hansel, Nadia N.; Hastie, Annette T.; Hoffman, Eric A.; Kaner, Robert J.; Krishnan, Jerry ; O'Neal, Wanda K.; Ortega, Victor E.; Paine, Robert ; Peters, Stephen P.; Wells, Michael ; Woodruff, Prescott G.; Martinez, Fernando J.; Curtis, Jeffrey L.; Huffnagle, Gary B.; Huang, Yvonne J.Clinical Center: Michigan (University of Michigan)2021NPJ Biofilms Microbiomeshttps://pubmed.ncbi.nlm.nih.gov/33547327https://www.ncbi.nlm.nih.gov/pmc/PMC7865064
MS156Modeling residential indoor concentrations of PM , NO , NO , and secondhand smoke in the Subpopulations and Intermediate Outcome Measures in COPD (SPIROMICS) Air study.Zusman, Marina ; Gassett, Amanda J.; Kirwa, Kipruto ; Barr, Graham ; Cooper, Christopher B.; Han, Meilan K.; Kanner, Richard E.; Koehler, Kirsten ; Ortega, Victor E.; Rd, Robert Paine; Paulin, Laura ; Pirozzi, Cheryl ; Rule, Ana ; Hansel, Nadia N.; Kaufman, Joel D.2021Indoor Airhttps://pubmed.ncbi.nlm.nih.gov/33037695https://www.ncbi.nlm.nih.gov/pmc/PMC8202242
MS191Ratio of FEV/Slow Vital Capacity of < 0.7 Is Associated With Clinical, Functional, and Radiologic Features of Obstructive Lung Disease in Smokers With Preserved Lung Function.Fortis, Spyridon ; Comellas, Alejandro P.; Bhatt, Surya P.; Hoffman, Eric A.; Han, Meilan K.; Bhakta, Nirav R.; Paine, Robert ; Ronish, Bonnie ; Kanner, Richard E.; Dransfield, Mark ; Hoesterey, Daniel ; Buhr, Russell G.; Barr, Graham ; Dolezal, Brett ; Ortega, Victor E.; Drummond, Bradley ; Arjomandi, Mehrdad ; Kaner, Robert J.; Kim, Victor ; Curtis, Jeffrey L.; Bowler, Russell P.; Martinez, Fernando ; Labaki, Wassim W.; Cooper, Christopher B.; O'Neal, Wanda K.; Criner, Gerald ; Hansel, Nadia N.; Krishnan, Jerry A.; Woodruff, Prescott ; Couper, David ; Tashkin, Donald ; Barjaktarevic, Igor Clinical Center: Iowa (University of Iowa)2021Chesthttps://pubmed.ncbi.nlm.nih.gov/33539837https://www.ncbi.nlm.nih.gov/pmc/PMC8295909
MS125The influence of social support on COPD outcomes mediated by depression.Turnier, Leonard ; Eakin, Michelle ; Woo, Han ; Dransfield, Mark ; Parekh, Trisha ; Krishnan, Jerry A.; Kanner, Richard ; Cooper, Christopher B.; Woodruff, Prescott G.; Wise, Robert ; Han, Meilan K.; Romero, Karina ; Paulin, Laura M.; Peters, Stephen ; Drummond, Brad ; Bleecker, Eugene R.; Bowler, Russell ; Comellas, Alejandro P.; Couper, David ; Paine, Robert ; Martinez, Fernando ; Barr, Graham ; Putcha, Nirupama ; Hansel, Nadia N.Clinical Center: Baltimore (Johns Hopkins University)2021PLoS Onehttps://pubmed.ncbi.nlm.nih.gov/33730034https://www.ncbi.nlm.nih.gov/pmc/PMC7968645
MS207A Risk Prediction Model for Mortality Among Smokers in the COPDGene® Study.Strand, Matthew ; Austin, Erin ; Moll, Matthew ; Pratte, Katherine A.; Regan, Elizabeth A.; Hayden, Lystra P.; Bhatt, Surya P.; Boriek, Aladin M.; Casaburi, Richard ; Silverman, Edwin K.; Fortis, Spyridon ; Ruczinski, Ingo ; Koegler, Harald ; Rossiter, Harry B.; Occhipinti, Mariaelena ; Hanania, Nicola A.; Gebrekristos, Hirut T.; Lynch, David A.; Kunisaki, Ken M.; Young, Kendra A.; Sieren, Jessica C.; Ragland, Margaret ; Hokanson, John E.; Lutz, Sharon M.; Make, Barry J.; Kinney, Gregory L.; Cho, Michael H.; Pistolesi, Massimo ; DeMeo, Dawn L.; Sciurba, Frank C.; Comellas, Alejandro P.; Diaz, Alejandro A.; Barjaktarevic, Igor ; Bowler, Russell P.; Kanner, Richard E.; Peters, Stephen P.; Ortega, Victor E.; Dransfield, Mark T.; Crapo, James D.Clinical Center: Denver (National Jewish Health)2020Chronic Obstr Pulm Dishttps://pubmed.ncbi.nlm.nih.gov/32877963https://www.ncbi.nlm.nih.gov/pmc/PMC7883903
MS159Association of Dysanapsis With Chronic Obstructive Pulmonary Disease Among Older AdultsSmith, Benjamin M.; Kirby, Miranda ; Hoffman, Eric A.; Kronmal, Richard A.; Aaron, Shawn D.; Allen, Norrina B.; Bertoni, Alain ; Coxson, Harvey O.; Cooper, Chris ; Couper, David J.; Criner, Gerard ; Dransfield, Mark T.; Han, Meilan K.; Hansel, Nadia N.; Jacobs, David R.; Kaufman, Joel D.; Lin, Ching-Long ; Manichaikul, Ani ; Martinez, Fernando J.; Michos, Erin D.; Oelsner, Elizabeth C.; Paine, Robert ; Watson, Karol E.; Benedetti, Andrea ; Tan, Wan C.; Bourbeau, Jean ; Woodruff, Prescott G.; Barr, Graham Clinical Center: New York (Columbia University)2020JAMAhttps://pubmed.ncbi.nlm.nih.gov/32515814https://www.ncbi.nlm.nih.gov/pmc/PMC7284296
MS121Association of Long-term Ambient Ozone Exposure With Respiratory Morbidity in Smokers.Paulin, Laura M.; Gassett, Amanda J.; Alexis, Neil E.; Kirwa, Kipruto ; Kanner, Richard E.; Peters, Stephen ; Krishnan, Jerry A.; Paine, Robert ; Dransfield, Mark ; Woodruff, Prescott G.; Cooper, Christopher B.; Barr, Graham ; Comellas, Alejandro P.; Pirozzi, Cheryl S.; Han, MeiLan ; Hoffman, Eric A.; Martinez, Fernando J.; Woo, Han ; Peng, Roger D.; Fawzy, Ashraf ; Putcha, Nirupama ; Breysse, Patrick N.; Kaufman, Joel D.; Hansel, Nadia N.Clinical Center: Baltimore (Johns Hopkins University)2020JAMA Intern Medhttps://pubmed.ncbi.nlm.nih.gov/31816012https://www.ncbi.nlm.nih.gov/pmc/PMC6902160
MS194Association of urine mitochondrial DNA with clinical measures of COPD in the SPIROMICS cohortZhang, William Z.; Rice, Michelle C.; Hoffman, Katherine L.; Oromendia, Clara ; Barjaktarevic, Igor Z.; Wells, Michael ; Hastie, Annette T.; Labaki, Wassim W.; Cooper, Christopher B.; Comellas, Alejandro P.; Criner, Gerard J.; Krishnan, Jerry A.; Paine, Robert ; Hansel, Nadia N.; Bowler, Russell P.; Barr, Graham ; Peters, Stephen P.; Woodruff, Prescott G.; Curtis, Jeffrey L.; Han, Meilan K.; Ballman, Karla V.; Martinez, Fernando J.; Choi, Augustine Mk; Nakahira, Kiichi ; Cloonan, Suzanne M.; Choi, Mary E.Weill Cornell Medical Center2020JCI Insighthttps://pubmed.ncbi.nlm.nih.gov/31895696https://www.ncbi.nlm.nih.gov/pmc/PMC7098791
MS158Associations Among 25-Hydroxyvitamin D Levels, Lung Function, and Exacerbation Outcomes in COPD: An Analysis of the SPIROMICS Cohort.Burkes, Robert M.; Ceppe, Agathe S.; Doerschuk, Claire M.; Couper, David ; Hoffman, Eric A.; Comellas, Alejandro P.; Barr, Graham ; Krishnan, Jerry A.; Cooper, Christopher ; Labaki, Wassim W.; Ortega, Victor E.; Wells, Michael ; Criner, Gerard J.; Woodruff, Prescott G.; Bowler, Russell P.; Pirozzi, Cheryl S.; Hansel, Nadia N.; Wise, Robert A.; Brown, Todd T.; Drummond, Bradley Genomics and Informatics Center (University of North Carolina at Chapel Hill)2020Chesthttps://pubmed.ncbi.nlm.nih.gov/31958447https://www.ncbi.nlm.nih.gov/pmc/PMC7118244
MS085Current smoking with or without chronic bronchitis is independently associated with goblet cell hyperplasia in healthy smokers and COPD subjects.Kim, Victor ; Jeong, Stephanie ; Zhao, Huaqing ; Kesimer, Mehmet ; Boucher, Richard C.; Wells, Michael ; Christenson, Stephanie A.; Han, Meilan K.; Dransfield, Mark ; Paine, Robert ; Cooper, Christopher B.; Barjaktarevic, Igor ; Bowler, Russell ; Curtis, Jeffrey L.; Kaner, Robert J.; O'Beirne, Sarah L.; O'Neal, Wanda K.; Rennard, Stephen I.; Martinez, Fernando J.; Woodruff, Prescott G.Clinical Center: Pennsylvania (Temple University)2020Sci Rephttps://pubmed.ncbi.nlm.nih.gov/33208859https://www.ncbi.nlm.nih.gov/pmc/PMC7674445
MS192Defining Chronic Mucus Hypersecretion Using the CAT in the SPIROMICS Cohort.Stott-Miller, Marni ; Müllerová, Hana ; Miller, Bruce ; Tabberer, Maggie ; Baou, Céline El; Keeley, Tom ; Martinez, Fernando J.; Han, MeiLan ; Dransfield, Mark ; Hansel, Nadia N.; Cooper, Christopher B.; Woodruff, Prescott ; Ortega, Victor E.; Comellas, Alejandro P.; Iii, Robert Paine; Kanner, Richard E.; Anderson, Wayne ; Drummond, Bradley ; Kim, Victor ; Tal-Singer, Ruth ; Lazaar, Aili L.2020Int J Chron Obstruct Pulmon Dishttps://pubmed.ncbi.nlm.nih.gov/33116463https://www.ncbi.nlm.nih.gov/pmc/PMC7568676
MS170Increased airway iron parameters and risk for exacerbation in COPD: an analysis from SPIROMICS.Zhang, William Z.; Oromendia, Clara ; Kikkers, Sarah Ann; Butler, James J.; O'Beirne, Sarah ; Kim, Kihwan ; O'Neal, Wanda K.; Freeman, Christine M.; Christenson, Stephanie A.; Peters, Stephen P.; Wells, Michael ; Doerschuk, Claire ; Putcha, Nirupama ; Barjaktarevic, Igor ; Woodruff, Prescott G.; Cooper, Christopher B.; Bowler, Russell P.; Comellas, Alejandro P.; Criner, Gerard J.; Paine, Robert ; Hansel, Nadia N.; Han, Meilan K.; Crystal, Ronald G.; Kaner, Robert J.; Ballman, Karla V.; Curtis, Jeffrey L.; Martinez, Fernando J.; Cloonan, Suzanne M.Weill Cornell Medical Center2020Sci Rephttps://pubmed.ncbi.nlm.nih.gov/32601308https://www.ncbi.nlm.nih.gov/pmc/PMC7324559
MS038Novel Respiratory Disability Score Predicts COPD Exacerbations and Mortality in the SPIROMICS Cohort.Cooper, Christopher B.; Paine, Robert ; Curtis, Jeffrey L.; Kanner, Richard E.; Martinez, Carlos H.; Meldrum, Catherine A.; Bowler, Russell ; O'Neal, Wanda ; Hoffman, Eric A.; Couper, David ; Quibrera, Miguel ; Criner, Gerald ; Dransfield, Mark T.; Han, Meilan K.; Hansel, Nadia N.; Krishnan, Jerry A.; Lazarus, Stephen C.; Peters, Stephen P.; Barr, Graham ; Martinez, Fernando J.; Woodruff, Prescott G.Clinical Center: Los Angeles (University of California at Los Angeles)2020Int J Chron Obstruct Pulmon Dishttps://pubmed.ncbi.nlm.nih.gov/32821092https://www.ncbi.nlm.nih.gov/pmc/PMC7417644
MS116Plasma Cathelicidin is Independently Associated with Reduced Lung Function in COPD: Analysis of the Subpopulations and Intermediate Outcome Measures in COPD Study Cohort.Burkes, Robert M.; Ceppe, Agathe S.; Couper, David J.; Comellas, Alejandro P.; Wells, Michael ; Peters, Stephen P.; Criner, Gerard J.; Kanner, Richard E.; Paine, Robert ; Christenson, Stephanie A.; Cooper, Christopher B.; Barjaktarevic, Igor Z.; Krishnan, Jerry A.; Labaki, Wassim W.; Han, Meilan K.; Curtis, Jeffrey L.; Hansel, Nadia N.; Wise, Robert A.; Drummond, Bradley Genomics and Informatics Center (University of North Carolina at Chapel Hill)2020Chronic Obstr Pulm Dishttps://pubmed.ncbi.nlm.nih.gov/33108110https://www.ncbi.nlm.nih.gov/pmc/PMC7883905
MS205Plasma Metabolomic Signatures of Chronic Obstructive Pulmonary Disease and the Impact of Genetic Variants on Phenotype-Driven Modules.Gillenwater, Lucas A.; Pratte, Katherine A.; Hobbs, Brian D.; Cho, Michael H.; Zhuang, Yonghua ; Halper-Stromberg, Eitan ; Cruickshank-Quinn, Charmion ; Reisdorph, Nichole ; Petrache, Irina ; Labaki, Wassim W.; O'Neal, Wanda K.; Ortega, Victor E.; Jones, Dean P.; Uppal, Karan ; Jacobson, Sean ; Michelotti, Gregory ; Wendt, Christine H.; Kechris, Katerina J.; Bowler, Russell P.Clinical Center: Denver (National Jewish Health)2020Netw Syst Medhttps://pubmed.ncbi.nlm.nih.gov/33987620https://www.ncbi.nlm.nih.gov/pmc/PMC8109053
MS023The Effects of Rare Variants on Lung Function and Emphysema in SPIROMICS.Ortega, Victor E.; Li, Xingnan ; O'Neal, Wanda K.; Lackey, Lela ; Ampleford, Elizabeth ; Hawkins, Gregory A.; Grayeski, Philip J.; Laederach, Alain ; Barjaktarevic, Igor ; Barr, Graham ; Cooper, Christopher ; Couper, David ; Han, Meilan K.; Kanner, Richard E.; Kleerup, Eric C.; Martinez, Fernando J.; Paine, Robert ; Peters, Stephen P.; Pirozzi, Cheryl ; Rennard, Stephen I.; Woodruff, Prescott G.; Hoffman, Eric A.; Meyers, Deborah A.; Bleecker, Eugene R.Clinical Center: Winston-Salem (Wake Forest University Health Sciences)2020Am J Respir Crit Care Medhttps://pubmed.ncbi.nlm.nih.gov/31661293https://www.ncbi.nlm.nih.gov/pmc/PMC7047460
MS119A Genetic Risk Score Associated with Chronic Obstructive Pulmonary Disease Susceptibility and Lung Structure on Computed Tomography.Oelsner, Elizabeth C.; Ortega, Victor E.; Smith, Benjamin M.; Nguyen, Jennifer N.; Manichaikul, Ani W.; Hoffman, Eric A.; Guo, Xiuqing ; Taylor, Kent D.; Woodruff, Prescott G.; Couper, David J.; Hansel, Nadia N.; Martinez, Fernando J.; Paine, Robert ; Han, Meilan K.; Cooper, Christopher ; Dransfield, Mark T.; Criner, Gerard ; Krishnan, Jerry A.; Bowler, Russell ; Bleecker, Eugene R.; Peters, Stephen ; Rich, Stephen S.; Meyers, Deborah A.; Rotter, Jerome I.; Barr, Graham Clinical Center: New York (Columbia University)2019Am J Respir Crit Care Medhttps://pubmed.ncbi.nlm.nih.gov/30925230https://www.ncbi.nlm.nih.gov/pmc/PMC6775892
MS094Alignment of Inhaled Chronic Obstructive Pulmonary Disease Therapies with Published Strategies. Analysis of the Global Initiative for Chronic Obstructive Lung Disease Recommendations in SPIROMICS.Ghosh, Sohini ; Anderson, Wayne H.; Putcha, Nirupama ; Han, Meilan K.; Curtis, Jeffrey L.; Criner, Gerard J.; Dransfield, Mark T.; Barr, Graham ; Krishnan, Jerry A.; Lazarus, Stephen C.; Cooper, Christopher B.; Paine, Robert ; Peters, Stephen P.; Hansel, Nadia N.; Martinez, Fernando J.; Drummond, Bradley Genomics and Informatics Center (University of North Carolina at Chapel Hill)2019Ann Am Thorac Sochttps://pubmed.ncbi.nlm.nih.gov/30216731https://www.ncbi.nlm.nih.gov/pmc/PMC6376942
MS081An airway epithelial IL-17A response signature identifies a steroid-unresponsive COPD patient subgroup.Christenson, Stephanie A.; van den Berge, Maarten ; Faiz, Alen ; Inkamp, Kai ; Bhakta, Nirav ; Bonser, Luke R.; Zlock, Lorna T.; Barjaktarevic, Igor Z.; Barr, Graham ; Bleecker, Eugene R.; Boucher, Richard C.; Bowler, Russell P.; Comellas, Alejandro P.; Curtis, Jeffrey L.; Han, Meilan K.; Hansel, Nadia N.; Hiemstra, Pieter S.; Kaner, Robert J.; Krishnanm, Jerry A.; Martinez, Fernando J.; O'Neal, Wanda K.; Paine, Robert ; Timens, Wim ; Wells, Michael ; Spira, Avrum ; Erle, David J.; Woodruff, Prescott G.Clinical Center: San Francisco (University of California at San Francisco)2019J Clin Investhttps://pubmed.ncbi.nlm.nih.gov/30383540https://www.ncbi.nlm.nih.gov/pmc/PMC6307967
MS112Aspirin Use and Respiratory Morbidity in COPD: A Propensity Score-Matched Analysis in Subpopulations and Intermediate Outcome Measures in COPD Study.Fawzy, Ashraf ; Putcha, Nirupama ; Aaron, Carrie P.; Bowler, Russell P.; Comellas, Alejandro P.; Cooper, Christopher B.; Dransfield, Mark T.; Han, Meilan K.; Hoffman, Eric A.; Kanner, Richard E.; Krishnan, Jerry A.; Labaki, Wassim W.; Paine, Robert ; Paulin, Laura M.; Peters, Stephen P.; Wise, Robert ; Barr, Graham ; Hansel, Nadia N.Clinical Center: Baltimore (Johns Hopkins University)2019Chesthttps://pubmed.ncbi.nlm.nih.gov/30593776https://www.ncbi.nlm.nih.gov/pmc/PMC6414789
MS203Bronchoalveolar Lavage Fluid from COPD Patients Reveals More Compounds Associated with Disease than Matched Plasma.Halper-Stromberg, Eitan ; Gillenwater, Lucas ; Cruickshank-Quinn, Charmion ; O'Neal, Wanda Kay; Reisdorph, Nichole ; Petrache, Irina ; Zhuang, Yonghua ; Labaki, Wassim W.; Curtis, Jeffrey L.; Wells, James ; Rennard, Stephen ; Pratte, Katherine A.; Woodruff, Prescott ; Stringer, Kathleen A.; Kechris, Katerina ; Bowler, Russell P.Clinical Center: Denver (National Jewish Health)2019Metaboliteshttps://pubmed.ncbi.nlm.nih.gov/31349744https://www.ncbi.nlm.nih.gov/pmc/PMC6724137
MS113Chronic lung disease in adult recurrent tuberculosis survivors in Zimbabwe: a cohort study.Chin, A T.; Rylance, J ; Makumbirofa, S ; Meffert, S ; Vu, T ; Clayton, J ; Mason, P ; Woodruff, P ; Metcalfe, J Clinical Center: San Francisco (University of California at San Francisco)2019Int J Tuberc Lung Dishttps://pubmed.ncbi.nlm.nih.gov/30808453https://www.ncbi.nlm.nih.gov/pmc/PMC6860915
MS006Clinical Significance of Bronchodilator Responsiveness Evaluated by Forced Vital Capacity in COPD: SPIROMICS Cohort Analysis.Barjaktarevic, Igor Z.; Buhr, Russell G.; Wang, Xiaoyan ; Hu, Scott ; Couper, David ; Anderson, Wayne ; Kanner, Richard E.; Iii, Robert Paine; Bhatt, Surya P.; Bhakta, Nirav R.; Arjomandi, Mehrdad ; Kaner, Robert J.; Pirozzi, Cheryl S.; Curtis, Jeffrey L.; O'Neal, Wanda K.; Woodruff, Prescott G.; Han, Meilan K.; Martinez, Fernando J.; Hansel, Nadia ; Wells, James Michael; Ortega, Victor E.; Hoffman, Eric A.; Doerschuk, Claire M.; Kim, Victor ; Dransfield, Mark T.; Drummond, Bradley ; Bowler, Russell ; Criner, Gerard ; Christenson, Stephanie A.; Ronish, Bonnie ; Peters, Stephen P.; Krishnan, Jerry A.; Tashkin, Donald P.; Cooper, Christopher B.Clinical Center: Los Angeles (University of California at Los Angeles)2019Int J Chron Obstruct Pulmon Dishttps://pubmed.ncbi.nlm.nih.gov/31908441https://www.ncbi.nlm.nih.gov/pmc/PMC6930016
MS181Elastin-Specific Autoimmunity in Smokers With Thoracic Aortic Aneurysm and Dissection is Independent of Chronic Obstructive Pulmonary Disease.Gu, Bon-Hee ; Choi, Justin C.; Shen, Ying H.; Song, Li-Zhen ; Scheurer, Michael E.; Luong, Amber ; Rodriguez, Antony ; Woodruff, Prescott ; Koth, Laura ; Corry, David B.; Kheradmand, Farrah ; LeMaire, Scott A.Clinical Center: San Francisco (University of California at San Francisco)2019J Am Heart Assochttps://pubmed.ncbi.nlm.nih.gov/30957625https://www.ncbi.nlm.nih.gov/pmc/PMC6507218
MS144Radiographic lung volumes predict progression to COPD in smokers with preserved spirometry in SPIROMICS.Arjomandi, Mehrdad ; Zeng, Siyang ; Barjaktarevic, Igor ; Barr, Graham ; Bleecker, Eugene R.; Bowler, Russell P.; Buhr, Russell G.; Criner, Gerard J.; Comellas, Alejandro P.; Cooper, Christopher B.; Couper, David J.; Curtis, Jeffrey L.; Dransfield, Mark T.; Han, Meilan K.; Hansel, Nadia N.; Hoffman, Eric A.; Kaner, Robert J.; Kanner, Richard E.; Krishnan, Jerry A.; Paine, Robert ; Peters, Stephen P.; Rennard, Stephen I.; Woodruff, Prescott G.Clinical Center: San Francisco (University of California at San Francisco)2019Eur Respir Jhttps://pubmed.ncbi.nlm.nih.gov/31439683https://www.ncbi.nlm.nih.gov/pmc/PMC7089627
MS122Safety and Tolerability of Comprehensive Research Bronchoscopy in Chronic Obstructive Pulmonary Disease. Results from the SPIROMICS Bronchoscopy Substudy.Wells, Michael ; Arenberg, Douglas A.; Barjaktarevic, Igor ; Bhatt, Surya P.; Bowler, Russell P.; Christenson, Stephanie A.; Couper, David J.; Dransfield, Mark T.; Han, Meilan K.; Hoffman, Eric A.; Kaner, Robert J.; Kim, Victor ; Kleerup, Eric ; Martinez, Fernando J.; Moore, Wendy C.; O'Beirne, Sarah L.; Paine, Robert ; Putcha, Nirupama ; Raman, Sanjeev M.; Barr, Graham ; Rennard, Stephen I.; Woodruff, Prescott G.; Curtis, Jeffrey L.Clinical Center: Birmingham (University of Alabama at Birmingham)2019Ann Am Thorac Sochttps://pubmed.ncbi.nlm.nih.gov/30653926https://www.ncbi.nlm.nih.gov/pmc/PMC6441692
MS145Serum amino acid concentrations and clinical outcomes in smokers: SPIROMICS metabolomics study.Labaki, Wassim W.; Gu, Tian ; Murray, Susan ; Curtis, Jeffrey L.; Yeomans, Larisa ; Bowler, Russell P.; Barr, Graham ; Comellas, Alejandro P.; Hansel, Nadia N.; Cooper, Christopher B.; Barjaktarevic, Igor ; Kanner, Richard E.; Paine, Robert ; McDonald, Merry-Lynn N.; Krishnan, Jerry A.; Peters, Stephen P.; Woodruff, Prescott G.; O'Neal, Wanda K.; Diao, Wenqi ; He, Bei ; Martinez, Fernando J.; Standiford, Theodore J.; Stringer, Kathleen A.; Han, Meilan K.Clinical Center: Michigan (University of Michigan)2019Sci Rephttps://pubmed.ncbi.nlm.nih.gov/31388056https://www.ncbi.nlm.nih.gov/pmc/PMC6684630
MS146Systemic Markers of Inflammation in Smokers With Symptoms Despite Preserved Spirometry in SPIROMICS.Garudadri, Suresh ; Woodruff, Prescott G.; Han, Meilan K.; Curtis, Jeffrey L.; Barr, Graham ; Bleecker, Eugene R.; Bowler, Russell P.; Comellas, Alejandro ; Cooper, Christopher B.; Criner, Gerard ; Dransfield, Mark T.; Hansel, Nadia N.; Paine, Robert ; Krishnan, Jerry A.; Peters, Stephen P.; Hastie, Annette T.; Martinez, Fernando J.; O'Neal, Wanda K.; Couper, David J.; Alexis, Neil E.; Christenson, Stephanie A.Clinical Center: San Francisco (University of California at San Francisco)2019Chesthttps://pubmed.ncbi.nlm.nih.gov/30684474https://www.ncbi.nlm.nih.gov/pmc/PMC6533449
MS198The matrikine acetyl-proline-glycine-proline and clinical features of COPD: findings from SPIROMICS.Wells, Michael ; Xing, Dongqi ; Viera, Liliana ; Burkes, Robert M.; Wu, Yixin ; Bhatt, Surya P.; Dransfield, Mark T.; Couper, David J.; O'Neal, Wanda ; Hoffman, Eric A.; Gaggar, Amit ; Barjaktarevic, Igor ; Curtis, Jeffrey L.; Labaki, Wassim W.; Han, Mei Lan K.; Freeman, Christine M.; Putcha, Nirupama ; Schlange, Thomas ; Blalock, Edwin Clinical Center: Birmingham (University of Alabama at Birmingham)2019Respir Reshttps://pubmed.ncbi.nlm.nih.gov/31718676https://www.ncbi.nlm.nih.gov/pmc/PMC6852714
MS080Alveolar eosinophilia in current smokers with chronic obstructive pulmonary disease in the SPIROMICS cohort.Martinez, Carlos H.; Li, Sara X.; Hirzel, Andrew J.; Stolberg, Valerie R.; Alexis, Neil E.; Barr, Graham ; Bleecker, Eugene R.; Carretta, Elizabeth E.; Christenson, Stephanie A.; Cooper, Christopher B.; Couper, David J.; Doerschuk, Claire M.; Han, Meilan K.; Hansel, Nadia N.; Hastie, Annette T.; Hoffman, Eric A.; Kaner, Robert J.; Martinez, Fernando J.; Meyers, Deborah A.; O'Neal, Wanda K.; Paine, Robert ; Putcha, Nirupama ; Rennard, Stephen I.; Woodruff, Prescott G.; Zeidler, Michelle ; Curtis, Jeffrey L.; Freeman, Christine M.Clinical Center: Michigan (University of Michigan)2018J Allergy Clin Immunolhttps://pubmed.ncbi.nlm.nih.gov/28916185https://www.ncbi.nlm.nih.gov/pmc/PMC5758424
MS022Association between Emphysema and Chronic Obstructive Pulmonary Disease Outcomes in the COPDGene and SPIROMICS Cohorts: A Post Hoc Analysis of Two Clinical Trials.Han, Meilan K.; Tayob, Nabihah ; Murray, Susan ; Woodruff, Prescott G.; Curtis, Jeffrey L.; Kim, Victor ; Criner, Gerard ; Galbán, Craig J.; Ross, Brian D.; Hoffman, Eric A.; Lynch, David A.; Kazerooni, Ella ; Martinez, Fernando J.Clinical Center: Michigan (University of Michigan)2018Am J Respir Crit Care Medhttps://pubmed.ncbi.nlm.nih.gov/29485901https://www.ncbi.nlm.nih.gov/pmc/PMC6058986
MS093Association of thrombocytosis with COPD morbidity: the SPIROMICS and COPDGene cohorts.Fawzy, Ashraf ; Putcha, Nirupama ; Paulin, Laura M.; Aaron, Carrie P.; Labaki, Wassim W.; Han, Meilan K.; Wise, Robert A.; Kanner, Richard E.; Bowler, Russell P.; Barr, Graham ; Hansel, Nadia N.Clinical Center: Baltimore (Johns Hopkins University)2018Respir Reshttps://pubmed.ncbi.nlm.nih.gov/29373977https://www.ncbi.nlm.nih.gov/pmc/PMC5787242
MS142Centrilobular emphysema and coronary artery calcification: mediation analysis in the SPIROMICS cohort.Bhatt, Surya P.; Nath, Hrudaya P.; Kim, Young-Il ; Ramachandran, Rekha ; Watts, Jubal R.; Terry, Nina L.J.; Sonavane, Sushil ; Deshmane, Swati P.; Woodruff, Prescott G.; Oelsner, Elizabeth C.; Bodduluri, Sandeep ; Han, Meilan K.; Labaki, Wassim W.; Wells, Michael ; Martinez, Fernando J.; Barr, Graham ; Dransfield, Mark T.Clinical Center: Birmingham (University of Alabama at Birmingham)2018Respir Reshttps://pubmed.ncbi.nlm.nih.gov/30563576https://www.ncbi.nlm.nih.gov/pmc/PMC6299495
MS077Elevated circulating MMP-9 is linked to increased COPD exacerbation risk in SPIROMICS and COPDGene.Wells, Michael ; Parker, Margaret M.; Oster, Robert A.; Bowler, Russ P.; Dransfield, Mark T.; Bhatt, Surya P.; Cho, Michael H.; Kim, Victor ; Curtis, Jeffrey L.; Martinez, Fernando J.; Paine, Robert ; O'Neal, Wanda ; Labaki, Wassim W.; Kaner, Robert J.; Barjaktarevic, Igor ; Han, Meilan K.; Silverman, Edwin K.; Crapo, James D.; Barr, Graham ; Woodruff, Prescott ; Castaldi, Peter J.; Gaggar, Amit Clinical Center: Birmingham (University of Alabama at Birmingham)2018JCI Insighthttps://pubmed.ncbi.nlm.nih.gov/30429371https://www.ncbi.nlm.nih.gov/pmc/PMC6302944
MS073Genome-wide association study of lung function and clinical implication in heavy smokers.Li, Xingnan ; Ortega, Victor E.; Ampleford, Elizabeth J.; Barr, Graham ; Christenson, Stephanie A.; Cooper, Christopher B.; Couper, David ; Dransfield, Mark T.; Han, Mei Lan K.; Hansel, Nadia N.; Hoffman, Eric A.; Kanner, Richard E.; Kleerup, Eric C.; Martinez, Fernando J.; Paine, Robert ; Woodruff, Prescott G.; Hawkins, Gregory A.; Bleecker, Eugene R.; Meyers, Deborah A.Clinical Center: Tucson (University of Arizona)2018BMC Med Genethttps://pubmed.ncbi.nlm.nih.gov/30068317https://www.ncbi.nlm.nih.gov/pmc/PMC6090900
MS041Heterogeneous burden of lung disease in smokers with borderline airflow obstruction.Pirozzi, Cheryl S.; Gu, Tian ; Quibrera, Pedro M.; Carretta, Elizabeth E.; Han, Meilan K.; Murray, Susan ; Cooper, Christopher B.; Tashkin, Donald P.; Kleerup, Eric C.; Barjaktarevic, Igor ; Hoffman, Eric A.; Martinez, Carlos H.; Christenson, Stephanie A.; Hansel, Nadia N.; Barr, Graham ; Bleecker, Eugene R.; Ortega, Victor E.; Martinez, Fernando J.; Kanner, Richard E.; Paine, Robert Clinical Center: Utah (University of Utah)2018Respir Reshttps://pubmed.ncbi.nlm.nih.gov/30454050https://www.ncbi.nlm.nih.gov/pmc/PMC6245799
MS053Human airway branch variation and chronic obstructive pulmonary disease.Smith, Benjamin M.; Traboulsi, Hussein ; Austin, John H.M.; Manichaikul, Ani ; Hoffman, Eric A.; Bleecker, Eugene R.; Cardoso, Wellington V.; Cooper, Christopher ; Couper, David J.; Dashnaw, Stephen M.; Guo, Jia ; Han, Meilan K.; Hansel, Nadia N.; Hughes, Emlyn W.; Jacobs, David R.; Kanner, Richard E.; Kaufman, Joel D.; Kleerup, Eric ; Lin, Ching-Long ; Liu, Kiang ; Cascio, Christian M.Lo; Martinez, Fernando J.; Nguyen, Jennifer N.; Prince, Martin R.; Rennard, Stephen ; Rich, Stephen S.; Simon, Leora ; Sun, Yanping ; Watson, Karol E.; Woodruff, Prescott G.; Baglole, Carolyn J.; Barr, Graham Clinical Center: New York (Columbia University)2018Proc Natl Acad Sci U S Ahttps://pubmed.ncbi.nlm.nih.gov/29339516https://www.ncbi.nlm.nih.gov/pmc/PMC5798356
MS063Imaging-based clusters in current smokers of the COPD cohort associate with clinical characteristics: the SubPopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS).Haghighi, Babak ; Choi, Sanghun ; Choi, Jiwoong ; Hoffman, Eric A.; Comellas, Alejandro P.; Newell, John D.; Barr, Graham ; Bleecker, Eugene ; Cooper, Christopher B.; Couper, David ; Han, Mei Lan; Hansel, Nadia N.; Kanner, Richard E.; Kazerooni, Ella A.; Kleerup, Eric A.C.; Martinez, Fernando J.; O'Neal, Wanda ; Rennard, Stephen I.; Woodruff, Prescott G.; Lin, Ching-Long Clinical Center: Iowa (University of Iowa)2018Respir Reshttps://pubmed.ncbi.nlm.nih.gov/30227877https://www.ncbi.nlm.nih.gov/pmc/PMC6145340
MS089Lower serum IgA is associated with COPD exacerbation risk in SPIROMICS.Putcha, Nirupama ; Paul, Gabriel G.; Azar, Antoine ; Wise, Robert A.; O'Neal, Wanda K.; Dransfield, Mark T.; Woodruff, Prescott G.; Curtis, Jeffrey L.; Comellas, Alejandro P.; Drummond, Bradley ; Lambert, Allison A.; Paulin, Laura M.; Fawzy, Ashraf ; Kanner, Richard E.; Paine, Robert ; Han, Meilan K.; Martinez, Fernando J.; Bowler, Russell P.; Barr, Graham ; Hansel, Nadia N.Clinical Center: Baltimore (Johns Hopkins University)2018PLoS Onehttps://pubmed.ncbi.nlm.nih.gov/29649230https://www.ncbi.nlm.nih.gov/pmc/PMC5896903
MS082Mucin Concentrations and Peripheral Airway Obstruction in Chronic Obstructive Pulmonary Disease.Kesimer, Mehmet ; Smith, Benjamin M.; Ceppe, Agathe ; Ford, Amina A.; Anderson, Wayne H.; Barr, Graham ; O'Neal, Wanda K.; Boucher, Richard C.Genomics and Informatics Center (University of North Carolina at Chapel Hill)2018Am J Respir Crit Care Medhttps://pubmed.ncbi.nlm.nih.gov/30130124https://www.ncbi.nlm.nih.gov/pmc/PMC6290944
MS095NT-proBNP in stable COPD and future exacerbation risk: Analysis of the SPIROMICS cohort.Labaki, Wassim W.; Xia, Meng ; Murray, Susan ; Curtis, Jeffrey L.; Barr, Graham ; Bhatt, Surya P.; Bleecker, Eugene R.; Hansel, Nadia N.; Cooper, Christopher B.; Dransfield, Mark T.; Wells, Michael ; Hoffman, Eric A.; Kanner, Richard E.; Paine, Robert ; Ortega, Victor E.; Peters, Stephen P.; Krishnan, Jerry A.; Bowler, Russell P.; Couper, David J.; Woodruff, Prescott G.; Martinez, Fernando J.; Martinez, Carlos H.; Han, Meilan K.Clinical Center: Michigan (University of Michigan)2018Respir Medhttps://pubmed.ncbi.nlm.nih.gov/29957287https://www.ncbi.nlm.nih.gov/pmc/PMC6084793
MS087Occupational Exposures and Computed Tomographic Imaging Characteristics in the SPIROMICS Cohort.Paulin, Laura M.; Smith, Benjamin M.; Koch, Abby ; Han, MeiLan ; Hoffman, Eric A.; Martinez, Carlos ; Ejike, Chinedu ; Blanc, Paul D.; Rous, Jennifer ; Barr, Graham ; Peters, Stephen P.; Paine, Robert ; Pirozzi, Cheryl ; Cooper, Christopher B.; Dransfield, Mark T.; Comellas, Alejandro P.; Kanner, Richard E.; Drummond, Brad ; Putcha, Nirupama ; Hansel, Nadia N.Clinical Center: Baltimore (Johns Hopkins University)2018Ann Am Thorac Sochttps://pubmed.ncbi.nlm.nih.gov/30339479https://www.ncbi.nlm.nih.gov/pmc/PMC6322018
MS092Rural Residence and Chronic Obstructive Pulmonary Disease Exacerbations. Analysis of the SPIROMICS Cohort.Burkes, Robert M.; Gassett, Amanda J.; Ceppe, Agathe S.; Anderson, Wayne ; O'Neal, Wanda K.; Woodruff, Prescott G.; Krishnan, Jerry A.; Barr, Graham ; Han, Meilan K.; Martinez, Fernando J.; Comellas, Alejandro P.; Lambert, Allison A.; Kaufman, Joel D.; Dransfield, Mark T.; Wells, Michael ; Kanner, Richard E.; Paine, Robert ; Bleecker, Eugene R.; Paulin, Laura M.; Hansel, Nadia N.; Drummond, Bradley Genomics and Informatics Center (University of North Carolina at Chapel Hill)2018Ann Am Thorac Sochttps://pubmed.ncbi.nlm.nih.gov/29584453https://www.ncbi.nlm.nih.gov/pmc/PMC6207115
MS012Sleep disruption as a predictor of quality of life among patients in the subpopulations and intermediate outcome measures in COPD study (SPIROMICS).Zeidler, Michelle R.; Martin, Jennifer L.; Kleerup, Eric C.; Schneider, Hartmut ; Mitchell, Michael N.; Hansel, Nadia N.; Sundar, Krishna ; Schotland, Helena ; Basner, Robert C.; Wells, Michael ; Krishnan, Jerry A.; Criner, Gerard J.; Cristenson, Stephanie ; Krachman, Samuel ; Badr, Safwan Clinical Center: Los Angeles (University of California at Los Angeles)2018Sleephttps://pubmed.ncbi.nlm.nih.gov/29534240https://www.ncbi.nlm.nih.gov/pmc/PMC5946919
MS051Age and Small Airway Imaging Abnormalities in Subjects with and without Airflow Obstruction in SPIROMICS.Martinez, Carlos H.; Diaz, Alejandro A.; Meldrum, Catherine ; Curtis, Jeffrey L.; Cooper, Christopher B.; Pirozzi, Cheryl ; Kanner, Richard E.; Paine, Robert ; Woodruff, Prescott G.; Bleecker, Eugene R.; Hansel, Nadia N.; Barr, Graham ; Marchetti, Nathaniel ; Criner, Gerard J.; Kazerooni, Ella A.; Hoffman, Eric A.; Ross, Brian D.; Galbán, Craig J.; Cigolle, Christine T.; Martinez, Fernando J.; Han, Meilan K.Clinical Center: Michigan (University of Michigan)2017Am J Respir Crit Care Medhttps://pubmed.ncbi.nlm.nih.gov/27564413https://www.ncbi.nlm.nih.gov/pmc/PMC5378423
MS082Airway Mucin Concentration as a Marker of Chronic Bronchitis.Kesimer, Mehmet ; Ford, Amina A.; Ceppe, Agathe ; Radicioni, Giorgia ; Cao, Rui ; Davis, William ; Doerschuk, Claire M.; Alexis, Neil E.; Anderson, Wayne H.; Henderson, Ashley G.; Barr, Graham ; Bleecker, Eugene R.; Christenson, Stephanie A.; Cooper, Christopher B.; Han, Meilan K.; Hansel, Nadia N.; Hastie, Annette T.; Hoffman, Eric A.; Kanner, Richard E.; Martinez, Fernando ; Paine, Robert ; Woodruff, Prescott G.; O'Neal, Wanda K.; Boucher, Richard C.Genomics and Informatics Center (University of North Carolina at Chapel Hill)2017N Engl J Medhttps://pubmed.ncbi.nlm.nih.gov/28877023https://www.ncbi.nlm.nih.gov/pmc/PMC5706541
MS029Association of sputum and blood eosinophil concentrations with clinical measures of COPD severity: an analysis of the SPIROMICS cohort.Hastie, Annette T.; Martinez, Fernando J.; Curtis, Jeffrey L.; Doerschuk, Claire M.; Hansel, Nadia N.; Christenson, Stephanie ; Putcha, Nirupama ; Ortega, Victor E.; Li, Xingnan ; Barr, Graham ; Carretta, Elizabeth E.; Couper, David J.; Cooper, Christopher B.; Hoffman, Eric A.; Kanner, Richard E.; Kleerup, Eric ; O'Neal, Wanda K.; Paine, Richard ; Peters, Stephen P.; Alexis, Neil E.; Woodruff, Prescott G.; Han, Meilan K.; Meyers, Deborah A.; Bleecker, Eugene R.Clinical Center: Winston-Salem (Wake Forest University Health Sciences)2017Lancet Respir Medhttps://pubmed.ncbi.nlm.nih.gov/29146301https://www.ncbi.nlm.nih.gov/pmc/PMC5849066
MS026Biomarkers Predictive of Exacerbations in the SPIROMICS and COPDGene Cohorts.Keene, Jason D.; Jacobson, Sean ; Kechris, Katerina ; Kinney, Gregory L.; Foreman, Marilyn G.; Doerschuk, Claire M.; Make, Barry J.; Curtis, Jeffrey L.; Rennard, Stephen I.; Barr, Graham ; Bleecker, Eugene R.; Kanner, Richard E.; Kleerup, Eric C.; Hansel, Nadia N.; Woodruff, Prescott G.; Han, Meilan K.; Paine, Robert ; Martinez, Fernando J.; Bowler, Russell P.; O'Neal, Wanda K.Clinical Center: Denver (National Jewish Health)2017Am J Respir Crit Care Medhttps://pubmed.ncbi.nlm.nih.gov/27579823https://www.ncbi.nlm.nih.gov/pmc/PMC5378424
MS045Cigarette smoke disrupts monolayer integrity by altering epithelial cell-cell adhesion and cortical tension.Nishida, Kristine ; Brune, Kieran A.; Putcha, Nirupama ; Mandke, Pooja ; O'Neal, Wanda K.; Shade, Danny ; Srivastava, Vasudha ; Wang, Menghan ; Lam, Hong ; An, Steven S.; Drummond, Bradley ; Hansel, Nadia N.; Robinson, Douglas N.; Sidhaye, Venkataramana K.Clinical Center: Baltimore (Johns Hopkins University)2017Am J Physiol Lung Cell Mol Physiolhttps://pubmed.ncbi.nlm.nih.gov/28642260https://www.ncbi.nlm.nih.gov/pmc/PMC5625260
MS008Comparison of low- and ultralow-dose computed tomography protocols for quantitative lung and airway assessment.Hammond, Emily ; Sloan, Chelsea ; Newell, John D.; Sieren, Jered P.; Saylor, Melissa ; Vidal, Craig ; Hogue, Shayna ; De Stefano, Frank ; Sieren, Alexa ; Hoffman, Eric A.; Sieren, Jessica C.Reading Center: Radiology (University of Iowa)2017Med Physhttps://pubmed.ncbi.nlm.nih.gov/28657201https://www.ncbi.nlm.nih.gov/pmc/PMC5603212
MS097Correcting Nonpathological Variation in Longitudinal Parametric Response Maps of CT Scans in COPD Subjects: SPIROMICS.Fernández-Baldera, Antonio ; Hatt, Charles R.; Murray, Susan ; Hoffman, Eric A.; Kazerooni, Ella A.; Martinez, Fernando J.; Han, Meilan K.; Galbán, Craig J.Clinical Center: Michigan (University of Michigan)2017Tomographyhttps://pubmed.ncbi.nlm.nih.gov/29457137https://www.ncbi.nlm.nih.gov/pmc/PMC5812694
MS083Electronic Cigarette Use in US Adults at Risk for or with COPD: Analysis from Two Observational Cohorts.Bowler, Russell P.; Hansel, Nadia N.; Jacobson, Sean ; Barr, Graham ; Make, Barry J.; Han, Meilan K.; O'Neal, Wanda K.; Oelsner, Elizabeth C.; Casaburi, Richard ; Barjaktarevic, Igor ; Cooper, Chris ; Foreman, Marilyn ; Wise, Robert A.; DeMeo, Dawn L.; Silverman, Edwin K.; Bailey, William ; Harrington, Kathleen F.; Woodruff, Prescott G.; Drummond, Bradley Clinical Center: Denver (National Jewish Health)2017J Gen Intern Medhttps://pubmed.ncbi.nlm.nih.gov/28884423https://www.ncbi.nlm.nih.gov/pmc/PMC5698219
MS034Frequency of exacerbations in patients with chronic obstructive pulmonary disease: an analysis of the SPIROMICS cohort.Han, Meilan K.; Quibrera, Pedro M.; Carretta, Elizabeth E.; Barr, Graham ; Bleecker, Eugene R.; Bowler, Russell P.; Cooper, Christopher B.; Comellas, Alejandro ; Couper, David J.; Curtis, Jeffrey L.; Criner, Gerard ; Dransfield, Mark T.; Hansel, Nadia N.; Hoffman, Eric A.; Kanner, Richard E.; Krishnan, Jerry A.; Martinez, Carlos H.; Pirozzi, Cheryl B.; O'Neal, Wanda K.; Rennard, Stephen ; Tashkin, Donald P.; Wedzicha, Jadwiga A.; Woodruff, Prescott ; Paine, Robert ; Martinez, Fernando J.Clinical Center: Michigan (University of Michigan)2017Lancet Respir Medhttps://pubmed.ncbi.nlm.nih.gov/28668356https://www.ncbi.nlm.nih.gov/pmc/PMC5558856
MS072Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis.Hobbs, Brian D.; de Jong, Kim ; Lamontagne, Maxime ; Bossé, Yohan ; Shrine, Nick ; Artigas, María Soler; Wain, Louise V.; Hall, Ian P.; Jackson, Victoria E.; Wyss, Annah B.; London, Stephanie J.; North, Kari E.; Franceschini, Nora ; Strachan, David P.; Beaty, Terri H.; Hokanson, John E.; Crapo, James D.; Castaldi, Peter J.; Chase, Robert P.; Bartz, Traci M.; Heckbert, Susan R.; Psaty, Bruce M.; Gharib, Sina A.; Zanen, Pieter ; Lammers, Jan W.; Oudkerk, Matthijs ; Groen, H J.; Locantore, Nicholas ; Tal-Singer, Ruth ; Rennard, Stephen I.; Vestbo, Jørgen ; Timens, Wim ; Paré, Peter D.; Latourelle, Jeanne C.; Dupuis, Josée ; O'Connor, George T.; Wilk, Jemma B.; Kim, Woo Jin; Lee, Mi Kyeong; Oh, Yeon-Mok ; Vonk, Judith M.; de Koning, Harry J.; Leng, Shuguang ; Belinsky, Steven A.; Tesfaigzi, Yohannes ; Manichaikul, Ani ; Wang, Xin-Qun ; Rich, Stephen S.; Barr, Graham ; Sparrow, David ; Litonjua, Augusto A.; Bakke, Per ; Gulsvik, Amund ; Lahousse, Lies ; Brusselle, Guy G.; Stricker, Bruno H.; Uitterlinden, André G.; Ampleford, Elizabeth J.; Bleecker, Eugene R.; Woodruff, Prescott G.; Meyers, Deborah A.; Qiao, Dandi ; Lomas, David A.; Yim, Jae-Joon ; Kim, Deog Kyeom; Hawrylkiewicz, Iwona ; Sliwinski, Pawel ; Hardin, Megan ; Fingerlin, Tasha E.; Schwartz, David A.; Postma, Dirkje S.; MacNee, William ; Tobin, Martin D.; Silverman, Edwin K.; Boezen, Marike ; Cho, Michael H.Clinical Center: Winston-Salem (Wake Forest University Health Sciences)2017Nat Genethttps://pubmed.ncbi.nlm.nih.gov/28166215https://www.ncbi.nlm.nih.gov/pmc/PMC5381275
MS078Respiratory Symptoms Items from the COPD Assessment Test Identify Ever-Smokers with Preserved Lung Function at Higher Risk for Poor Respiratory Outcomes. An Analysis of the Subpopulations and Intermediate Outcome Measures in COPD Study Cohort.Martinez, Carlos H.; Murray, Susan ; Barr, Graham ; Bleecker, Eugene ; Bowler, Russell P.; Christenson, Stephanie A.; Comellas, Alejandro P.; Cooper, Christopher B.; Couper, David ; Criner, Gerard J.; Curtis, Jeffrey L.; Dransfield, Mark T.; Hansel, Nadia N.; Hoffman, Eric A.; Kanner, Richard E.; Kleerup, Eric ; Krishnan, Jerry A.; Lazarus, Stephen C.; Leidy, Nancy K.; O'Neal, Wanda ; Martinez, Fernando J.; Paine, Robert ; Rennard, Stephen I.; Tashkin, Donald P.; Woodruff, Prescott G.; Han, Meilan K.Clinical Center: Michigan (University of Michigan)2017Ann Am Thorac Sochttps://pubmed.ncbi.nlm.nih.gov/28459622https://www.ncbi.nlm.nih.gov/pmc/PMC5427740
MS075Subpopulations and Intermediate Outcomes in COPD (SPIROMICS) Air Pollution Study DesignHansel, Nadia N.; Paulin, Laura M.; Amanda, Gassett ; Roger, Peng ; Alexis, Neil E.; Fan, Vincent ; Bleecker, Eugene ; Bowler, Russell P.; Comellas, Alejandro P.; Dransfield, Mark T.; Han, Meilan K.; Kim, Victor ; Krishnan, Jerry A.; Pirozzi, Cheryl ; Cooper, Christopher B.; Martinez, Fernando J.; Woodruff, Prescott G.; Patrick, Breysse ; Barr, Graham ; Kaufman, Joel Clinical Center: Baltimore (Johns Hopkins University)2017BJM Open Respiratory Research
MS107The value of blood cytokines and chemokines in assessing COPD.Bradford, Eric ; Jacobson, Sean ; Varasteh, Jason ; Comellas, Alejandro P.; Woodruff, Prescott ; O'Neal, Wanda ; DeMeo, Dawn L.; Li, Xingnan ; Kim, Victor ; Cho, Michael ; Castaldi, Peter J.; Hersh, Craig ; Silverman, Edwin K.; Crapo, James D.; Kechris, Katerina ; Bowler, Russell P.Clinical Center: Denver (National Jewish Health)2017Respir Reshttps://pubmed.ncbi.nlm.nih.gov/29065892https://www.ncbi.nlm.nih.gov/pmc/PMC5655820
MS056Variability in objective and subjective measures affects baseline values in studies of patients with COPD.Anderson, Wayne H.; Ha, Jae Wook; Couper, David J.; O'Neal, Wanda K.; Barr, Graham ; Bleecker, Eugene R.; Carretta, Elizabeth E.; Cooper, Christopher B.; Doerschuk, Claire M.; Drummond, Bradley ; Han, Meilan K.; Hansel, Nadia N.; Kim, Victor ; Kleerup, Eric C.; Martinez, Fernando J.; Rennard, Stephen I.; Tashkin, Donald ; Woodruff, Prescott G.; Paine, Robert ; Curtis, Jeffrey L.; Kanner, Richard E.Genomics and Informatics Center (University of North Carolina at Chapel Hill)2017PLoS Onehttps://pubmed.ncbi.nlm.nih.gov/28934249https://www.ncbi.nlm.nih.gov/pmc/PMC5608200
MS068A controlled statistical study to assess measurement variability as a function of test object position and configuration for automated surveillance in a multicenter longitudinal COPD study (SPIROMICS).Guo, Junfeng ; Wang, Chao ; Chan, Kung-Sik ; Jin, Dakai ; Saha, Punam K.; Sieren, Jered P.; Barr, R G.; Han, Meilan K.; Kazerooni, Ella ; Cooper, Christopher B.; Couper, David ; Newell, John D.; Hoffman, Eric A.Clinical Center: Iowa (University of Iowa)2016Med Physhttps://pubmed.ncbi.nlm.nih.gov/27147369https://www.ncbi.nlm.nih.gov/pmc/PMC4851622
MS036Age-Related Differences in Health-Related Quality of Life in COPD: An Analysis of the COPDGene and SPIROMICS Cohorts.Martinez, Carlos H.; Diaz, Alejandro A.; Parulekar, Amit D.; Rennard, Stephen I.; Kanner, Richard E.; Hansel, Nadia N.; Couper, David ; Holm, Kristen E.; Hoth, Karin F.; Curtis, Jeffrey L.; Martinez, Fernando J.; Hanania, Nicola A.; Regan, Elizabeth A.; Paine, Robert ; Cigolle, Christine T.; Han, Meilan K.Clinical Center: Michigan (University of Michigan)2016Chesthttps://pubmed.ncbi.nlm.nih.gov/26836895https://www.ncbi.nlm.nih.gov/pmc/PMC4944781
MS032Clinical Significance of Symptoms in Smokers with Preserved Pulmonary Function.Woodruff, Prescott G.; Barr, Graham ; Bleecker, Eugene ; Christenson, Stephanie A.; Couper, David ; Curtis, Jeffrey L.; Gouskova, Natalia A.; Hansel, Nadia N.; Hoffman, Eric A.; Kanner, Richard E.; Kleerup, Eric ; Lazarus, Stephen C.; Martinez, Fernando J.; Paine, Robert ; Rennard, Stephen ; Tashkin, Donald P.; Han, Meilan K.Clinical Center: San Francisco (University of California at San Francisco)2016N Engl J Medhttps://pubmed.ncbi.nlm.nih.gov/27168432https://www.ncbi.nlm.nih.gov/pmc/PMC4968204
MS016Common Genetic Polymorphisms Influence Blood Biomarker Measurements in COPD.Sun, Wei ; Kechris, Katerina ; Jacobson, Sean ; Drummond, Bradley ; Hawkins, Gregory A.; Yang, Jenny ; Chen, Ting-Huei ; Quibrera, Pedro Miguel; Anderson, Wayne ; Barr, Graham ; Basta, Patricia V.; Bleecker, Eugene R.; Beaty, Terri ; Casaburi, Richard ; Castaldi, Peter ; Cho, Michael H.; Comellas, Alejandro ; Crapo, James D.; Criner, Gerard ; Demeo, Dawn ; Christenson, Stephanie A.; Couper, David J.; Curtis, Jeffrey L.; Doerschuk, Claire M.; Freeman, Christine M.; Gouskova, Natalia A.; Han, Meilan K.; Hanania, Nicola A.; Hansel, Nadia N.; Hersh, Craig P.; Hoffman, Eric A.; Kaner, Robert J.; Kanner, Richard E.; Kleerup, Eric C.; Lutz, Sharon ; Martinez, Fernando J.; Meyers, Deborah A.; Peters, Stephen P.; Regan, Elizabeth A.; Rennard, Stephen I.; Scholand, Mary Beth; Silverman, Edwin K.; Woodruff, Prescott G.; O'Neal, Wanda K.; Bowler, Russell P.Genomics and Informatics Center (University of North Carolina at Chapel Hill)2016PLoS Genethttps://pubmed.ncbi.nlm.nih.gov/27532455https://www.ncbi.nlm.nih.gov/pmc/PMC4988780
MS008SPIROMICS Protocol for Multicenter Quantitative Computed Tomography to Phenotype the Lungs.Sieren, Jered P.; Newell, John D.; Barr, Graham ; Bleecker, Eugene R.; Burnette, Nathan ; Carretta, Elizabeth E.; Couper, David ; Goldin, Jonathan ; Guo, Junfeng ; Han, Meilan K.; Hansel, Nadia N.; Kanner, Richard E.; Kazerooni, Ella A.; Martinez, Fernando J.; Rennard, Stephen ; Woodruff, Prescott G.; Hoffman, Eric A.Reading Center: Radiology (University of Iowa)2016Am J Respir Crit Care Medhttps://pubmed.ncbi.nlm.nih.gov/27482984https://www.ncbi.nlm.nih.gov/pmc/PMC5074650
MS037Understanding the impact of second-hand smoke exposure on clinical outcomes in participants with COPD in the SPIROMICS cohort.Putcha, Nirupama ; Barr, Graham ; Han, Meilan K.; Woodruff, Prescott G.; Bleecker, Eugene R.; Kanner, Richard E.; Martinez, Fernando J.; Smith, Benjamin M.; Tashkin, Donald P.; Bowler, Russell P.; Eisner, Mark D.; Rennard, Stephen I.; Wise, Robert A.; Hansel, Nadia N.Clinical Center: Baltimore (Johns Hopkins University)2016Thoraxhttps://pubmed.ncbi.nlm.nih.gov/26962015https://www.ncbi.nlm.nih.gov/pmc/PMC5235992
MS017Design of a multi-center immunophenotyping analysis of peripheral blood, sputum and bronchoalveolar lavage fluid in the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS).Freeman, Christine M.; Crudgington, Sean ; Stolberg, Valerie R.; Brown, Jeanette P.; Sonstein, Joanne ; Alexis, Neil E.; Doerschuk, Claire M.; Basta, Patricia V.; Carretta, Elizabeth E.; Couper, David J.; Hastie, Annette T.; Kaner, Robert J.; O'Neal, Wanda K.; Paine, Robert ; Rennard, Stephen I.; Shimbo, Daichi ; Woodruff, Prescott G.; Zeidler, Michelle ; Curtis, Jeffrey L.Clinical Center: Michigan (University of Michigan)2015J Transl Medhttps://pubmed.ncbi.nlm.nih.gov/25622723https://www.ncbi.nlm.nih.gov/pmc/PMC4314767
MS013Occupational exposures are associated with worse morbidity in patients with chronic obstructive pulmonary disease.Paulin, Laura M.; Diette, Gregory B.; Blanc, Paul D.; Putcha, Nirupama ; Eisner, Mark D.; Kanner, Richard E.; Belli, Andrew J.; Christenson, Stephanie ; Tashkin, Donald P.; Han, MeiLan ; Barr, Graham ; Hansel, Nadia N.Clinical Center: Baltimore (Johns Hopkins University)2015Am J Respir Crit Care Medhttps://pubmed.ncbi.nlm.nih.gov/25562375https://www.ncbi.nlm.nih.gov/pmc/PMC4384767
MS019Parametric response mapping monitors temporal changes on lung CT scans in the subpopulations and intermediate outcome measures in COPD Study (SPIROMICS).Boes, Jennifer L.; Hoff, Benjamin A.; Bule, Maria ; Johnson, Timothy D.; Rehemtulla, Alnawaz ; Chamberlain, Ryan ; Hoffman, Eric A.; Kazerooni, Ella A.; Martinez, Fernando J.; Han, Meilan K.; Ross, Brian D.; Galbán, Craig J.Clinical Center: Michigan (University of Michigan)2015Acad Radiolhttps://pubmed.ncbi.nlm.nih.gov/25442794https://www.ncbi.nlm.nih.gov/pmc/PMC4289437
MS010A simplified score to quantify comorbidity in COPD.Putcha, Nirupama ; Puhan, Milo A.; Drummond, Bradley ; Han, Meilan K.; Regan, Elizabeth A.; Hanania, Nicola A.; Martinez, Carlos H.; Foreman, Marilyn ; Bhatt, Surya P.; Make, Barry ; Ramsdell, Joe ; DeMeo, Dawn L.; Barr, Graham ; Rennard, Stephen I.; Martinez, Fernando ; Silverman, Edwin K.; Crapo, James ; Wise, Robert A.; Hansel, Nadia N.Clinical Center: Baltimore (Johns Hopkins University)2014PLoS Onehttps://pubmed.ncbi.nlm.nih.gov/25514500https://www.ncbi.nlm.nih.gov/pmc/PMC4267736
MS005Comparison of serum, EDTA plasma and P100 plasma for luminex-based biomarker multiplex assays in patients with chronic obstructive pulmonary disease in the SPIROMICS study.O'Neal, Wanda K.; Anderson, Wayne ; Basta, Patricia V.; Carretta, Elizabeth E.; Doerschuk, Claire M.; Barr, Graham ; Bleecker, Eugene R.; Christenson, Stephanie A.; Curtis, Jeffrey L.; Han, Meilan K.; Hansel, Nadia N.; Kanner, Richard E.; Kleerup, Eric C.; Martinez, Fernando J.; Miller, Bruce E.; Peters, Stephen P.; Rennard, Stephen I.; Scholand, Mary Beth; Tal-Singer, Ruth ; Woodruff, Prescott G.; Couper, David J.; Davis, Sonia M.Genomics and Informatics Center (University of North Carolina at Chapel Hill)2014J Transl Medhttps://pubmed.ncbi.nlm.nih.gov/24397870https://www.ncbi.nlm.nih.gov/pmc/PMC3928911
MS018Comparison of spatially matched airways reveals thinner airway walls in COPD. The Multi-Ethnic Study of Atherosclerosis (MESA) COPD Study and the Subpopulations and Intermediate Outcomes in COPD Study (SPIROMICS).Smith, Benjamin M.; Hoffman, Eric A.; Rabinowitz, Dan ; Bleecker, Eugene ; Christenson, Stephanie ; Couper, David ; Donohue, Kathleen M.; Han, Meilan K.; Hansel, Nadia N.; Kanner, Richard E.; Kleerup, Eric ; Rennard, Stephen ; Barr, Graham Clinical Center: New York (Columbia University)2014Thoraxhttps://pubmed.ncbi.nlm.nih.gov/24928812https://www.ncbi.nlm.nih.gov/pmc/PMC4198462
MS002Design of the Subpopulations and Intermediate Outcomes in COPD Study (SPIROMICS).Couper, David ; LaVange, Lisa M.; Han, MeiLan ; Barr, Graham ; Bleecker, Eugene ; Hoffman, Eric A.; Kanner, Richard ; Kleerup, Eric ; Martinez, Fernando J.; Woodruff, Prescott G.; Rennard, Stephen Genomics and Informatics Center (University of North Carolina at Chapel Hill)2014Thoraxhttps://pubmed.ncbi.nlm.nih.gov/24029743https://www.ncbi.nlm.nih.gov/pmc/PMC3954445
MS001The COPD ontology and toward empowering clinical scientists as ontology engineersgreenberg, jane ; O'Neal, Wanda ; Deshmukh, Rahul ; Lina, Huang ; Mostafa, Javed ; LaVange, Lisa M.; Carretta, Elizabeth E.Genomics and Informatics Center (University of North Carolina at Chapel Hill)2010Journal of Library Metadata